Male mice and their wild-type controls were evaluated at 7-10 months of age using the 5-Choice Serial Reaction Time (5-CSRT) task to assess attention. Immediately after (approximately at 9-12 months of age) these same mice were evaluated using the Extinction task to assess their ability to extinguish a response. A different cohort of male mice and their wild-type controls were evaluated at 11-13 months of age in the Pairwise visual discrimination (PVD) task to assess discrimination and reversal learning. Immediately after (still within 11-13 months of age) these same mice were evaluated using the Pairwise Associate Learning (PAL) task to assess learning and memory. Creators: Dr. Marco Prado Licenses: CC0 Version: 1 Modalities: Cognitive Behavioral Data Formats: CSV Size: 5.0 MB Number of files: 12 Number of Subjects: 53 Github Sources: https://mousebytes.ca/data-extraction Primary Publications: Selective decrease of cholinergic signaling from pedunculopontine and laterodorsal tegmental nuclei has little impact on cognition but markedly increases susceptibility to stress.. Helena Janickova et al.. the Journal of the Federation American Societies for Experimental Biology...
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Brainstem cholinergic-deficient mouse model dataset is published on Viral AI.