Prenatal maternal immune activation (MIA) is a risk factor for neurodevelopmental disorders, such as Autism Spectrum Disorder and Schizophrenia. The data presented here result from a study of how the gestational timing of MIA-exposure differentially impacts downstream development. They include longitudinal structural magnetic resonance imaging (MRI) data from weaning to adulthood, and behavioural testing in adolescence and adulthood on C57BL/6 mice exposed to MIA induced by the viral mimetic polyinosinic:polycytidylic acid (poly I:C), either early (gestational day GD9) or late (GD17) in gestation. More details concerning the data, methods, and results can be found in Guma et al., 2021: https://doi.org/10.1016/j.biopsych.2021.03.017. Please consult the dataset’s README for additional information about the dataset and a summary of the study’s findings. Creators: Elisa Guma; Gabriel A Devenyi; Daniel Gallino; Chloe Anastassiadis; Emily Snook; Jurgen Germann; M Mallar Chakravarty Licenses: CC-BY-4.0 Version: 1.2 Modalities: Pre-processed structural MRI data (MINC format) and behavioural data Formats: CSV, MNC, TXT Size: 3.3 GB Number of files: 386 Number of Subjects: 95 Github...
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Longitudinal structural MRI and behavioural data for mice prenatally exposed to maternal immune activation either early or late in gestation is published on Viral AI.