This dataset has data files from 5-Choice Serial Reaction Time (5-CSRT), Pairwise Visual Discrimination (PVD), and Extinction cognitive behavioral tasks for 4 mouse lines that differ in neurotransmitter release from striatal cholinergic interneurons (ACh or Glu). D2CreVGLUT3fx and ChATIRESVGLUT3fx mice and their wild-type controls were evaluated at 3-7 months of age in the PVD task to assess discrimination and reversal learning. Immediately after (still within 3-7 months of age) these same mice were evaluated using the Extinction task to assess their ability to extinguish a response. D2CreVAChTfx mice and their wild-type controls were evaluated at 5-7 months of age in the 5-CSRT task to assess attention. Immediately after (still within 3-7 months of age) these same mice were evaluated using the Extinction task. VAChTfx control mice that were virally injected with GFP or Cre in the dorsal striatum were evaluated at 6-12 months in the PVD task, followed by the 5-CSRT task (approximately at 8-14 months of age). Creators: Dr. Marco Prado Licenses: CC0 Version: 1 Modalities: Cognitive Behavioral Data Formats: CSV Size: 9.0 MB Number of files: 22 Number of Subjects: 103 Github...
Access is restricted by the data custodian. The collection's description and structure are public; the data is not available for querying through this network.
Mouse models that differ in neurotransmitter release from striatal cholinergic interneurons is published on Viral AI.